Gastric Microbiota Gender Differences in Subjects with Healthy Stomachs and Autoimmune Atrophic Gastritis

Gender differences and microbiota are gaining increasing attention. This study aimed to assess gender in gastric bacterial between subjects with healthy stomachs those autoimmune atrophic gastritis. was a post hoc analysis of 52 undergoing gastroscopy for dyspepsia (57.7% stomach, 42.3% gastritis). Gastric biopsies were obtained histopathology genomic DNA extraction. assessed by sequencing the hypervariable regions 16SrRNA gene. The profile at phylum level reported as being relative abundance expressed OTUs (>0.5%) biodiversity calculated Shannon-diversity index-H. All data stratified female male gender. Results showed that women had higher less microbial diversity compared men. Likely due hypochlorhydria non-acid intragastric environment, gastritis seems reset reduce males, showing greater extent dysbiosis terms reduced Differences on taxa frequency genus observed. impact these findings gender-specific natural history remains be elucidated; any case, should deserve attention studies.